Premium
Primary biliary cirrhosis–autoimmune hepatitis overlap syndrome: Simplified criteria may be effective in the diagnosis in C hinese patients
Author(s) -
Liu Fang,
Pan Zhen Guo,
Ye Jin,
Xu Dong,
Guo Hui,
Li Gang Ping,
Xu Ke Shu,
Hou Xiao Hua,
Song Yu Hu
Publication year - 2014
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12196
Subject(s) - medicine , overlap syndrome , autoimmune hepatitis , primary biliary cirrhosis , gastroenterology , cirrhosis , medical record , hepatitis c , hepatitis , disease
Objective To evaluate the P aris criteria, the revised diagnostic criteria and the simplified diagnostic scoring system in the diagnosis of primary biliary cirrhosis ( PBC )–autoimmune hepatitis ( AIH ) overlap syndrome in C hinese patients. Methods Medical records of the patients who were diagnosed with PBC at the Union Hospital and T ongji Hospital, Tongji Medical University, Huazhong University of Science and Technology ( W uhan, H ubei P rovince, C hina) from 2003 to 2012 were retrospectively reviewed. The overlap syndrome was diagnosed based on the P aris criteria, the revised criteria and the simplified criteria, respectively. Patients' clinical characteristics, laboratory examination results and histological findings were collected. The sensitivity and specificity of the three criteria for diagnosing PBC – AIH overlap syndrome were calculated.Results PBC – AIH overlap syndrome was diagnosed in 2, 13 and 10 patients with PBC based on the P aris, the revised and the simplified criteria, respectively. The sensitivity and specificity of the simplified criteria in diagnosing the overlap syndrome was 90.0% and 98.2%, which were the highest among the three criteria, followed by the revised criteria. The P aris criteria showed a high specificity (100%) but a relatively low sensitivity (20.0%). In addition, some patients who did not fulfil the P aris criteria still benefited from the immunosuppressive agents. Conclusions For C hinese patients with the PBC – AIH overlap syndrome, the simplified criteria appear to be the most efficacious compared with the P aris criteria and the revised criteria. Further studies should be performed to confirm these observations with respect to long‐term outcomes and therapeutic implications.