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Influence of family history on survival in patients with colon and rectal cancer
Author(s) -
Lee Seong Dae,
Kim Byung Chang,
Han Kyung Su,
Hong Chang Won,
Sohn Dae Kyung,
Park Ji Won,
Park Sung Chan,
Kim Sun Young,
Baek JiYeon,
Chang Hee Jin,
Kim Dae Yong,
Oh Jae Hwan
Publication year - 2014
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12120
Subject(s) - medicine , colorectal cancer , carcinoembryonic antigen , stage (stratigraphy) , hazard ratio , oncology , rectum , gastroenterology , cancer , multivariate analysis , confidence interval , paleontology , biology
Objective We aimed to investigate the association between a family history (FH) of colorectal cancer (CRC) and cancer recurrence and survival in patients with stage III CRC.Methods From A pril 2001 to D ecember 2007, 1102 patients with stage III CRC were enrolled and their data including FH, clinicopathological characteristics of the tumor were retrospectively analyzed. Results Of 971 patients that were finally enrolled, 63 (6.5%) reported CRC in at least one first‐degree relative. Death occurred in 12.7% of the CRC patients with an FH and 21.8% in those without an FH. A multivariate analysis showed that patients with an FH of CRC, compared with those without FH , had an adjusted hazard ratios ( HR ) of 0.674 ( P = 0.281) for overall survival ( OS ) and 0.672 ( P = 0.220) for disease‐free survival ( DFS ). However, the location of tumor, preoperative carcinoembryonic antigen ( CEA ) level, tumor invasion ( T ) stage and lymph node ( N ) metastasis significantly affected OS and DFS . Furthermore, whereas the FH of CRC patients was associated with a favorable prognosis in stage III colon cancer (HR 0.224, P = 0.040) but not in rectal cancer (HR 1.225, P = 0.640). Conclusions I n patients with stage III CRC , tumor location (especially in the rectum), a high preoperative CEA level and advanced T and N stages indicate a poor prognosis. However, in stage III colon cancer FH is associated with improved survival.