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T usanqi and hepatic sinusoidal obstruction syndrome
Author(s) -
Wang Ji Yao,
Gao Hong
Publication year - 2014
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12112
Subject(s) - ascites , medicine , pyrrolizidine , etiology , histopathology , gastroenterology , steatohepatitis , hepatic function , pathology , cirrhosis , disease , fatty liver , bioinformatics , biology
Hepatic sinusoidal obstruction syndrome ( HSOS ), characterized by hepatomegaly, ascites and hyperbilirubinemia, is caused by toxic injury to hepatic sinusoidal endothelial cells. One major etiology of HSOS in C hina is the intake of products containing pyrrolizidine alkaloids ( PA ) such as T usanqi. The manifestations of patients with HSOS are usually non‐specific, presenting with abnormal liver function and portal hypertension. Diagnosis of the disease depends mostly on liver histopathology when clinical and imaging data are not sufficient. A history of T usanqi intake is mostly important for the diagnosis. Due to a lack of effective, evidence‐based treatments for HSOS, avoiding the mistaken use of PA ‐containing products including T usanqi is important for the prevention of HSOS .