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Liver transplantation for hepatocellular carcinoma: Recent advances in C hina
Author(s) -
Lu Tian Fei,
Hua Xiang Wei,
Cui Xiao Lan,
Xia Qiang
Publication year - 2014
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12111
Subject(s) - medicine , hepatocellular carcinoma , liver transplantation , transplantation , surgery , pleural effusion , diabetes mellitus , endocrinology
Orthotopic liver transplantation is currently the best treatment option for selected patients with hepatocellular carcinoma ( HCC ). From 1980 to 2011, 8874 patients with HCC in China underwent liver transplantation. The organ donation classification criteria of C hina ( C hina criteria), which are established by the G overnment of C hina, are divided into three parts: C hina criteria I , donation after brain death; C hina criteria II , donation after cardiac death and C hina criteria III , donation after dual brain‐cardiac death. Data from the C hina L iver T ransplant Registry (CLTR) S ystem shows that patients within the M ilan criteria have higher survival rates than those who are beyond these criteria. Based on CLTR data, altogether 416 patients received living‐donor liver transplantation (LDLT) in China. Their 1‐year and 3‐year survival rates were significantly higher than those of the non‐ LDLT recipients. The most common early stage (<30 days after liver transplantation) complications include pleural effusion, diabetes, peritoneal effusion or abscess, postoperative infection, hypertension and intraperitoneal hemorrhage; while the most common late stage (≥30 days after liver transplantation) complications were diabetes, hypertension, biliary complications, postoperative infection, tacrolimus toxicity and chronic graft rejection. The incidence of vascular complication, which is the main reason for acute graft failure and re‐transplantation, was 2.4%. Liver transplantation is an effective treatment for patients with HCC in C hina.