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Prevalence of celiac disease in I ranian patients with irritable bowel syndrome: A cross‐sectional study
Author(s) -
Shayesteh Ali Akbar,
Hajiani Eskandar,
Hashemi Seyed Jalal,
Masjedizadeh Abdolrahim,
Latifi Seyed Mahmod,
Shayesteh Mehdi
Publication year - 2014
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12102
Subject(s) - medicine , irritable bowel syndrome , gastroenterology , diarrhea , tissue transglutaminase , antibody , cross sectional study , gluten free , disease , biopsy , immunology , pathology , biochemistry , chemistry , enzyme
Objective This study was aimed to determine the prevalence of celiac disease (CD) in irritable bowel syndrome (IBS) and its subtypes in a group of Iranian patients. Methods From M arch 2007 to J une 2009, 465 consecutive patients who were referred to the gastroenterology clinic of Jundishapur University of Medical Sciences and fulfilled the Rome III criteria for IBS were included. Immunoglobulin A (IgA) anti‐tissue transglutaminase (IgA‐tTG) and anti‐gliadin antibody ( AGA ) levels were measured. CD was confirmed by gastroduodenoscopy and biopsy in patients with abnormal antibodies. Results Five patients had only elevated IgA‐tTG, 26 with only elevated AGA , and in 16 patients abnormal results for both antibodies were reported. Duodenal biopsies from these 47 patients confirmed CD in 13 (2.8%, 95% CI 1.6–4.0%) according to the Marsh criteria. Two CD patients had normal IgA‐tTG concentrations while only one patient with normal AGA was proven to have CD . CD was most prevalent in unsubtyped IBS (4.9%, 95% CI 1.1–8.7%), followed by mixed IBS (4.7%, 95% CI 0.3–9.1%). In multiple comparison, CD was less common in diarrhea‐predominant IBS than in unsubtyped IBS , although this did not reach statistical significance (1.0% vs 4.9%, P = 0.057). Conclusions CD in unsubtyped IBS had a growing trend to be more common than in diarrhea‐predominant IBS. Evaluation of IBS patients for CD is advisable.