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Factors for hepatitis B vaccination and abnormal liver function in C hinese patients with inflammatory bowel disease: A single center experience
Author(s) -
Leung Wai K,
Liu Kevin SH,
Seto WaiKay Walter,
Chan KwokHung,
Tong Teresa,
Yuen ManFung,
Lai ChingLung,
Hung Ivan FN
Publication year - 2013
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12089
Subject(s) - medicine , inflammatory bowel disease , vaccination , thiopurine methyltransferase , gastroenterology , ulcerative colitis , hepatitis b , hepatitis b virus , liver function , disease , immunology , virus
Objectives We aimed to determine the prevalence of chronic and past hepatitis B virus (HBV) infection in Chinese patients with inflammatory bowel disease (IBD), and to determine the risk factors associated with having received no vaccination for HBV and abnormal liver function among our patients. Methods The prevalence of chronic or past infection with HBV infection and effective HBV vaccination were determined in patients with IBD who attended the IBD Clinic of the Queen Mary Hospital in Hong Kong, China. Risk factors associated with the absence of HBV vaccination and abnormal liver function were identified. Results A total of 267 C hinese IBD patients (166 ulcerative colitis and 101 C rohn's disease) were enrolled. The mean follow‐up period was 10.5 years. Chronic and past HBV infection was detected in 6.7% and 28.5% patients, respectively. Altogether 102 patients lacked effective HBV vaccination. Multivariate analysis found that elder age at diagnosis of IBD ( OR 1.02, 95% CI 1.00–0.94) and the absence of using thiopurine ( OR 0.53, 95% CI 0.29–0.94) were associated with the presence of anti‐HBs. A bnormal liver function was detected in 27 (10.1%) patients. The use of anti‐tumor necrosis factor agents ( OR 4.6, 95% CI 1.3−16.0), previous bowel resection ( OR 3.7, 95% CI 1.5–9.2) and male gender ( OR 4.4, 95% CI 1.4−13.7) were significant risk factors for abnormal liver function. Conclusions The use of thiopurine and younger age at diagnosis were associated with no vaccination against HBV in Chinese IBD patients. Chronic or past HBV infection was, however, not associated with abnormal liver function in these patients.