High‐definition magnifying endoscopy with i‐scan in the diagnosis of H elicobacter pylori infection: A pilot study

Objective This study aimed to compare the diagnostic value and image quality of high‐definition magnifying white light endoscopy ( M ‐ WLE ) and high‐definition magnifying endoscopy with i‐scan ( M ‐i‐scan) for H elicobacter pylori ( H . pylori ) infection. Methods Patients complaining of dyspepsia who underwent esophagogastroduodenoscopy at the Endoscopy Unit of Q ilu Hospital ( J inan, S handong Province, C hina) from January to M arch, 2011 were prospectively recruited. The greater curvature of the stomach was carefully observed using both M ‐ WLE and M ‐i‐scan. The gastric mucosal classification and image quality scores were recorded. The relationship between gastric mucosal classification and final diagnosis of H . pylori infection was determined. Results A total of 84 patients were recruited in this study. The accuracy and specificity of the combination of types 2–3 patterns predicting H . pylori infection were significantly higher for M ‐i‐scan than those for M ‐ WLE (accuracy: 94.0% vs 84.5%, P  = 0.046; and specificity: 93.5% vs 80.6%, P  = 0.032), while the sensitivity of the two modes was the same. The M ‐i‐scan provided a better image quality for H . pylori infection than M ‐ WLE ( P  < 0.001). Conclusion The M ‐i‐scan may be superior to M ‐ WLE for the prediction of H . pylori infection, but its diagnostic sensitivity needs to be improved.