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New insights on the pathomechanisms of inflammatory bowel disease
Author(s) -
Abdullah Murdani,
Syam Ari Fahrial,
Simadibrata Marcellus,
Gunawan Jeffri,
Makmun Dadang,
Rani Abdul Aziz
Publication year - 2013
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12081
Subject(s) - pathogenesis , inflammatory bowel disease , immune system , medicine , immunology , disease , inflammation , pathophysiology , ulcerative colitis , bioinformatics , biology , pathology
Pathogenesis of inflammatory bowel disease (IBD) remains an enigma on whether germs, genes or a combination of these two with excessive immune responses to gut‐associated bacteria explicates its pathomechanisms. The incidence of IBD is 0.76747 per 100 000 in C entral I ndonesia, as shown in the P roject I ndonesian IBD ACCESS 2012 progress report. This result, together with other epidemiological studies in Asia, may conclusively reflect increased rates of the disease, while its pathogenesis still undoubtedly obscured. However, knowledge of the pathophysiology of IBD is rapidly growing, abreast with new developments. A series of recent updates in core pathomechanisms such as bacterial, endoplasmic reticulum stress, new immune cell populations, T ‐cell differentiation and function, mucosal immune defenses and oxidative stress are relevant pathomechanism keypoints in IBD .