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Value of 18 F‐FDG‐PET/CT in the detection of recurrent hepatocellular carcinoma after hepatectomy or radiofrequency ablation: A comparative study with contrast‐enhanced ultrasound
Author(s) -
Wang Xiao Yan,
Chen Dong,
Zhang Xiang Song,
Chen Zhi Feng,
Hu An Bin
Publication year - 2013
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12064
Subject(s) - medicine , hepatocellular carcinoma , hepatectomy , contrast enhanced ultrasound , radiofrequency ablation , radiology , ultrasound , positron emission tomography , nuclear medicine , ablation , resection , surgery
Objective To evaluate the role of positron emission tomography/computer tomography with fluorine‐18 fluorodeoxyglucose ( 18 F‐FDG‐PET/CT ) in detecting hepatocellular carcinoma ( HCC ) recurrence after hepatectomy and/or radiofrequency ablation ( RFA ) and to compare its efficacy with contrast‐enhanced ultrasound ( CEUS ). Methods A total of 36 HCC patients were included in this study. All patients underwent both 18 F ‐ FDG ‐ PET / CT and CEUS at least once for the diagnosis of HCC recurrence. The time interval between PET / CT and CEUS was 14 ± 3 days. All patients were followed up for at least 24 months. Results In all, 32 patients were confirmed to have HCC recurrence by pathology and clinical follow‐up. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 18 F‐FDG‐PET/CT for intrahepatic HCC recurrence were 96.7%, 83.3%, 96.7%, 83.3% and 94.4%, respectively. The corresponding values of CEUS were 56.7%, 100%, 100%, 31.6% and 63.9%, respectively. The sensitivity and accuracy of 18 F‐FDG‐PET/CT for the diagnosis of HCC recurrence were significantly higher than those of CEUS ( P < 0.01, respectively). Conclusions Compared with CEUS , 18 F‐FDG‐PET/CT has higher sensitivity and accuracy in detecting the local recurrence of HCC after hepatectomy and/or RFA . It can be used to detect recurrent extrahepatic lesions of HCC effectively.