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A novel approach for the detection of early gastric cancer: Fluorescence spectroscopy of gastric juice
Author(s) -
Deng Kai,
Zhou Li Ya,
Lin San Ren,
Li Yuan,
Chen Mo,
Geng Qiu Ming,
Li Yu Wen
Publication year - 2013
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12040
Subject(s) - medicine , gastroenterology , cancer , endoscopy , confidence interval , fluorescence spectroscopy , gastritis , atrophic gastritis , receiver operating characteristic , fluorescence , stomach , physics , quantum mechanics
Objective This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer ( EGC ) screening. Methods Gastric juice was collected from 101 participants who underwent endoscopy in the O utpatient E ndoscopy C enter of P eking U niversity T hird H ospital. The participants were divided into three groups: the normal mucosa or chronic non‐atrophic gastritis ( NM‐CNAG ) group ( n = 35), advanced gastric cancer ( AGC ) group ( n = 33) and EGC group ( n = 33). Fluorescence spectroscopic analysis was performed in all the gastric juice samples and the maximum fluorescence intensity of the first peak ( P 1 FI ) was measured. Results The mean fluorescence intensity of P 1 FI of gastric juice in AGC (92.1 ± 10.7) and EGC (90.8 ± 12.0) groups was significantly higher than that in the NM‐CNAG group (55.7 ± 7.5) ( AGC vs NM‐CNAG , P = 0.006 and EGC vs NM‐CNAG , P = 0.015, respectively). The areas under the receiver operating characteristic curves for the detection of AGC and EGC were 0.681 (95% confidence interval [ CI ] 0.553–0.810, P = 0.010) and 0.655 (95% CI 0.522–0.787, P = 0.028). With the P 1 FI of ≥47.7, the sensitivity, specificity and accuracy for detecting EGC were 69.7%, 57.1% and 63.2%, respectively. Conclusions The enhancement of P 1 FI of gastric juice occurs at the early stage of gastric cancer. Fluorescence spectroscopy of gastric juice may be used as a novel screening tool for the early detection of gastric cancer.