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Columnar‐lined esophagus in C hinese patients with proximal gastric carcinomas
Author(s) -
Sun Qi,
Huang Qin,
Feng An Ning,
Fan Xiang Shan,
Wu Hong Yan,
Mashimo Hiroshi,
Zhou Qiang,
Chen Jin,
Lauwers Gregory Y.
Publication year - 2013
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12007
Subject(s) - intestinal metaplasia , gastroenterology , medicine , dysplasia , esophagus , stomach , helicobacter pylori , cancer , metaplasia , pathology
Objective To investigate the clinicopathological features of columnar‐lined esophagus ( CLE ) in Chinese patients.Methods Among 182 consecutive resections of proximal gastric cancer with residual esophageal tissue, 114 were eligible for the study. The maximal lengths of CLE and superficial esophageal glands ( SEG ) and the presence or absence of chronic inflammation ( CI ), lymphoid follicles ( LF ), Helicobacter pylori ( H. pylori ) infection, intestinal metaplasia ( IM ), pancreatic metaplasia ( PM ) and dysplasia were analyzed and compared with those in the adjacent proximal gastric mucosa. Results SEG were present in 110 cases with a mean length of 5.4 mm (range 1–16 mm, 90% equal to or under 10 mm and 10% between 11–16 mm). These glands were associated with CI (95%), LF (85%), H. pylori infection (42%), IM (25%), PM (36%) and dysplasia (10%). CLE was found in 65% of the cases and was associated with SEG (mean length of 4.0 mm, range 1–13 mm, 97% within 10 mm and 3% between 11–13 mm). The frequencies of CI (97%), LF (86%), H. pylori infection (65%) and PM (46%) in CLE were similar to those in the proximal stomach ( CI 90%, LF 54%, H. pylori infection 58%, PM 39%). In contrast, the frequencies of IM (37%) and dysplasia (15%) in CLE were significantly lower than those in the proximal stomach (66% and 31%, respectively; P < 0.01). Conclusions CLE in C hinese patients was within 10 mm in length in 97% of cases, and with SEG and H. pylori infection‐related changes similar to those in the proximal stomach.