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Effects of Banafine ® , a fermented green banana‐derived acidic glycoconjugate, on influenza vaccine antibody titer in elderly patients receiving gastrostomy tube feeding
Author(s) -
Horie Kenji,
Hossain Md. Saddam,
Kim Yugweng,
Akiko Ishida,
Kon Ryoko,
Yamatsu Atsushi,
Kishima Masako,
Nishikimi Toshio,
Kim Mujo
Publication year - 2021
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/1750-3841.15675
Subject(s) - medicine , vaccination , seroconversion , antibody , antibody titer , titer , immunology
Immunosenescence can negatively affect cytokine production in elderly and may impair poor antibody responses to influenza vaccination and infection. Herein, the effects of Banafine ® administration on influenza vaccine antibody titer in elderly patients (average age ∼80 years) receiving gastrostomy tube feeding were examined. In the double‐blind, single‐center, randomized clinical studies, 30 elderly bedridden patients were administered Banafine ® or placebo for 8 weeks. At week 4, all patients received influenza vaccination against H1N1, H3N2, B/Yamagata, or B/Victoria. Blood biochemical indices and serum antibody titers were assessed. Banafine ® administration significantly increased hemagglutination inhibition titers in response to vaccination against H1N1, H3N2, and B/Yamagata in the elderly patients ( P < 0.05). Moreover, the seroconversion rate against H1N1 (47.1%) and H3N2 (29.4%) and seroprotection rate against H1N1 (71.4%) and both B strains (31.3% and 12.5%, respectively) were increased for the Banafine ® group. These results suggest that Banafine ® administration can increase antibody responses to influenza vaccination in bedridden hospitalized patients, and potentially modulate immune function in the elderly. Practical Application Literature review suggested that most of the synbiotics are based on innate immunity, strain specific (probiotics), and are not consistently observed. Herein, in clinical studies we demonstrate that administration of Banafine ® , a plant‐based glycoconjugate, can increase antibody levels in bedridden hospitalized elderly patients following influenza vaccination.