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Effects and molecular mechanisms of Ninghong black tea extract in nonalcoholic fatty liver disease of rats
Author(s) -
Shen Yu,
Xiao Xiaojuan,
Wu Kunlu,
Wang Yanpeng,
Yuan Yijun,
Liu Jianwei,
Sun Shuming,
Liu Jing
Publication year - 2020
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/1750-3841.14846
Subject(s) - nonalcoholic fatty liver disease , chemistry , triglyceride , peroxisome , very low density lipoprotein , endocrinology , beta oxidation , medicine , downregulation and upregulation , fatty acid , fatty liver , biochemistry , lipoprotein , receptor , biology , gene , cholesterol , disease
The aim of this study is to observe the effects of Ninghong black tea extract on fat deposition and high‐fat diet‐induced nonalcoholic fatty liver disease (NAFLD) and to explore the potential mechanisms of these effect. Under 2% Ninghong black tea extract diet feeding in rat model, the results showed that Ninghong black tea extract decreased the body fat ratio and the number of lipid droplets in the liver and significantly alleviated NAFLD in the rat model. The real‐time fluorescence quantitative polymerase chain reaction results showed that Ninghong black tea extract significantly upregulated the expression of peroxisome proliferator‐activated receptor α (PPARα), which is important in fatty acid β‐oxidation, and microsomal triglyceride transfer protein (MTP), which plays an important role in the synthesis of very low density lipoprotein (VLDL). By promoting the expression of PPARα and MTP in liver tissue and thereby promoting fatty acid β‐oxidation and VLDL synthesis, Ninghong black tea extract relieves high‐fat diet‐induced NAFLD.