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Neuromodulatory Activity of Dietary Phenolics Derived from Corchorus olitorius L.
Author(s) -
Wagdy Reham,
Abdelkader Reham M.,
ElKhatib Ahmed H.,
Linscheid Michael W.,
Hamdi Nabila,
Handoussa Heba
Publication year - 2019
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/1750-3841.14587
Subject(s) - neuroinflammation , neurodegeneration , neuroprotection , chemistry , corchorus olitorius , pharmacology , microglia , biochemistry , biology , inflammation , medicine , botany , immunology , disease
Dietary phenolics are known for their potent antioxidant and anti‐inflammatory activities, making them promising candidates for protection against neuroinflammation and neurodegeneration. Hydroalcohol extract of Egyptian species of Corchorus olitorius L. ( Co ) leaves was investigated for its neuroprotective effects in a lipopolysaccharide‐induced neuroinflammatory mouse model. Twenty five metabolites were characterized from the bioactive extract using high‐performance liquid chromatography HPLC/PDA/HRESI/MS n , revealing 1,5‐dicaffeoylquinic acid ( Co 11) as one of the major constituents (5.7%), which was isolated and its identity was confirmed by spectral data as first report. Co significantly protected microglia against H 2 O 2 ‐induced cytotoxicity and immunohistochemistry showed reduced expression of the astrocytic marker, glial fibrillary acidic protein, and the inflammatory marker, cyclooxygenase‐2. These findings correlated with significant improvement of cognitive functions and reduction of LPS‐induced neurodegeneration in Co ‐treated mice as revealed by histopathology. The current study shows promising effects of Co in limiting neurodegeneration and cognitive impairment caused by neuroinflammation and glial cell activation. Practical Application Information presented here shed light on the promising effects of Corchorus olitorius ( Co ) for the modulation of neuroinflammatory pathways improving the neuroinflammation‐related neurodegeneration and cognitive decline. This makes Co a promising candidate as a nutraceutical supplement to be used against neuroinflammation‐related disorders.