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Hypoglycemic Activity of Polysaccharides from Sweet Corncob on Streptozotocin‐Induced Diabetic Rats
Author(s) -
Ma Yong Qiang,
Wang Xin,
Gao Shuang
Publication year - 2017
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/1750-3841.13554
Subject(s) - streptozotocin , chemistry , polysaccharide , diabetes mellitus , endocrinology , medicine , triglyceride , galactose , cholesterol , biochemistry
A water‐soluble polysaccharide (SCP‐80‐I) was isolated from sweet corncob using microwave‐assisted compound‐enzyme extraction and column chromatography. SCP‐80‐I is composed mainly of arabinose, mannose, glucose, and galactose in a molar ratio of 0.369:0.824:10.759:0.333, and has a molecular mass of 18350 Da and β‐glycosides linkages in its molecular structure. The preliminary hypoglycemic and hypolipidemic activity in streptozotocin‐induced diabetic rats was investigated. Rats were administered daily with 100, 200, and 400 mg/kg SCP‐80‐I for 21 d. The SCP‐80‐I increased the rat body mass significantly and reduced the blood glucose level in a dose‐dependent manner. The SCP‐80‐I reduced liver swelling; kidney and pancreas hypertrophy; and total cholesterol, triglyceride, and low‐density lipoprotein‐C levels significantly; and increased the level of high‐density lipoproteins in streptozotocin‐induced diabetic rats. These results indicate that SCP‐80‐I exerts a potential hypoglycemic effect in streptozotocin‐induced diabetic rats.