Core‐Shell Collagen Peptide Chelated Calcium/Calcium Alginate Nanoparticles from Fish Scales for Calcium Supplementation

We report simple methods for preparing collagen peptide chelated calcium (cpcc) and a novel cpcc‐loaded nanoparticle from marine fish scales for calcium supplementation. Cpcc nanoparticles have an average diameter of approximately 150 nm and a calcium content of up to 130.4 g/kg. Calcium alginate was selected to encapsulate cpcc for the preparation of core‐shell cpcc/calcium alginate nanoparticles. The core‐shell nanoparticles were mainly 200 to 500 nm in diameter. The ratio of calcium to sulfur was approximately 1.6:1. In vivo experiments indicated both cpcc and core‐shell cpcc were able to improve calcium absorption and prevent calcium deficiency. Especially core‐shell cpcc worked well to increase femur bone mineral density and femur calcium content in rats significantly. The study demonstrated that cpcc and core‐shell cpcc nanoparticles were ideal for calcium supplementation.