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Evaluation of Protective Effect of Freeze‐Dried Strawberry, Grape, and Blueberry Powder on Acrylamide Toxicity in Mice
Author(s) -
Zhao Mengyao,
Liu Xin,
Luo Yinghua,
Guo Huan,
Hu Xiaosong,
Chen Fang
Publication year - 2015
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/1750-3841.12815
Subject(s) - genotoxicity , toxicity , micronucleus , antioxidant , sperm , food science , acrylamide , micronucleus test , reproductive toxicity , chemistry , sperm motility , grape seed extract , biology , botany , biochemistry , medicine , organic chemistry , copolymer , polymer , alternative medicine , pathology
Berries are dietary plants with high antioxidant activity. The aim of this study is to investigate the protective effect of berries (strawberry, grape, and blueberry) against the acrylamide (AA)‐induced general toxicity, genotoxicity, and reproductive toxicity in mice model, respectively. Mice were treated with 50 mg/kg b.w./day AA intraperitoneal injection for 5 d after feeding control diet or diet containing freeze‐dried strawberry, grape, and blueberry powder. The results showed that AA induced a significant general toxicity, genotoxicity, and reproductive toxicity in mice. Compared with the control diet, the diets containing berries could reverse the AA‐induced alterations in liver antioxidant enzymes activities ( P < 0.05). Moreover, the AA‐induced genotoxicity could be prevented by the diet containing berries. The DNA damage in the lymphocyte and liver cells and the micronucleus formation in bone marrow cell were significantly alleviated ( P < 0.05). Meanwhile, the mice fed with diets containing berries showed a recovery in the sperm count, the sperm activity rate, sperm motility parameters, and the abnormal sperm rate ( P < 0.05). Berry powders have remarkable intervention against the AA‐induced general toxicity, genotoxicity, reproductive toxicity. Abundant phenolics, especially anthocyanins, may contribute to the intervention.