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Fenoxycarb promotes adipogenesis in 3T3‐L1 preadipocytes
Author(s) -
Lim Seonyoung,
Choi Hojung,
Park SungSoo,
Kim Minsoo,
Kim Eungseok
Publication year - 2016
Publication title -
entomological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 20
eISSN - 1748-5967
pISSN - 1738-2297
DOI - 10.1111/1748-5967.12151
Subject(s) - adipogenesis , adipocyte , nuclear receptor , biology , medicine , endocrinology , peroxisome proliferator activated receptor , receptor , lipid metabolism , farnesoid x receptor , juvenile hormone , hormone , adipose tissue , biochemistry , transcription factor , gene
Lipophilic insect hormones and their analogs affect mammalian physiology by regulating the expression of metabolic genes. Therefore, we determined the effect of fenoxycarb, a juvenile hormone analog, on lipid metabolism in adipocytes. Here, we demonstrated that fenoxycarb dose‐dependently promoted lipid accumulation in 3 T 3‐ L 1 adipocytes during adipocyte differentiation and that its lipogenic effect was comparable to that of rosiglitazone, a well‐known ligand for peroxisome proliferator‐activated receptor gamma ( PPARγ ). Furthermore, fenoxycarb stimulated PPARγ activity without affecting other nuclear receptors, such as liver X receptor ( LXR ), farnesoid X ‐activated receptor ( FXR ) and N ur77. In addition, fenoxycarb treatment increased the expression of PPARγ and fatty acid transporter protein 1 ( FATP1 ) in 3 T 3‐ L 1 adipocytes, suggesting that fenoxycarb may facilitate adipocyte differentiation by enhancing PPARγ signaling, the master regulator of adipogenesis. Together, our results suggest that fenoxycarb promoted lipid accumulation in adipocytes, in part, by stimulating PPARγ .