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Effect of high polyphenol extra virgin olive oil on markers of cardiovascular disease risk in healthy Australian adults (OLIVAUS): A protocol for a double‐blind randomised, controlled, cross‐over study
Author(s) -
Marx Wolfgang,
George Elena S.,
Mayr Hannah L.,
Thomas Colleen J.,
Sarapis Katerina,
Moschonis George,
Kennedy Greg,
Pipingas Andrew,
Willcox Jane C.,
Prendergast Luke A.,
Itsiopoulos Catherine
Publication year - 2020
Publication title -
nutrition and dietetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.479
H-Index - 31
eISSN - 1747-0080
pISSN - 1446-6368
DOI - 10.1111/1747-0080.12531
Subject(s) - mediterranean diet , medicine , polyphenol , olive oil , crossover study , context (archaeology) , population , polyunsaturated fatty acid , food science , physiology , environmental health , placebo , fatty acid , biochemistry , pathology , antioxidant , biology , paleontology , alternative medicine
Background Previous clinical studies have suggested that high polyphenol extra virgin olive oil (EVOO) provides a superior cardioprotective effect compared to low polyphenol olive oil. However, further studies are required to replicate these results in non‐Mediterranean populations. Aim To investigate the effect of high polyphenol EVOO versus low polyphenol olive oil with known polyphenol composition on markers of cardiovascular disease risk in a healthy non‐Mediterranean cohort. Methods In a double‐blind randomised cross‐over trial, the present study will examine the effect of high polyphenol EVOO versus low polyphenol olive oil in 50 healthy participants. Each intervention phase will be 3 weeks long with a 2‐week washout period between each phase. Outcomes to be assessed include HDL cholesterol efflux, oxidised LDL, blood lipids, C‐reactive protein, arterial stiffness, blood pressure and cognitive function. Dietary intake, physical activity levels and anthropometry will also be collected. Discussion Because of the rigorous trial design, novel and clinically relevant outcomes, the use of a well‐characterised EVOO, and, in contrast to the current literature, the non‐Mediterranean study population, the present study will provide a significant contribution to the understanding of the clinical importance of polyphenol intake in the Australian sociocultural context.