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Comparison of myoglobin clearance in three types of blood purification modalities
Author(s) -
Suzuki Shinya,
Moriyama Kazuhiro,
Hara Yoshitaka,
Hinoue Takuya,
Kato Yu,
Hasegawa Daisuke,
Kuriyama Naohide,
Nakamura Tomoyuki,
Komatsu Satoshi,
Yamashita Chizuru,
Komura Hidefumi,
Nishida Osamu
Publication year - 2021
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.13657
Subject(s) - myoglobin , medicine , clearance , renal function , blood flow , clearance rate , membrane , hemofiltration , cardiology , urology , biomedical engineering , hemodialysis , biochemistry , chemistry
Myoglobin, which can cause acute kidney injury, has a relatively high molecular weight and is poorly cleared by diffusion. We compared and examined myoglobin clearance by changing the blood purification membrane and modality in patients with a myoglobin blood concentration ≥ 1000 ng/ml. We retrospectively analyzed three patient groups based on the following three types of continuous hemofiltration (CHF): AN69ST membrane, polymethylmethacrylate (PMMA) membrane, and high‐flow hemodiafiltration (HDF) with increased dialysate flow rate using the PMMA membrane. There was no significant difference in clearance in CHF between AN69ST and PMMA membranes. However, the high‐flow HDF group showed the highest myoglobin clearance ( p = 0.003). In the PMMA membrane, changing the treatment modality to high‐flow HDF increased clearance above the theoretical value, possibly due to internal filtration. To remove myoglobin by kidney replacement therapy from patients with hypermyoglobinemia, a modality such as high‐flow HDF would be desirable.