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Effect of type 2 diabetes mellitus on efficacy and safety of therapeutic apheresis for severe hypertriglyceridemia
Author(s) -
Bagir Gulay Simsek,
Bakiner Okan Sefa,
Haydardedeoglu Filiz Eksi,
Araz Filiz,
Ertorer Melek Eda,
Kozanoglu İlknur
Publication year - 2021
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.13603
Subject(s) - medicine , hypertriglyceridemia , apheresis , dyslipidemia , adverse effect , gastroenterology , diabetes mellitus , therapeutic effect , type 2 diabetes mellitus , pancreatitis , plasmapheresis , hyperlipidemia , retrospective cohort study , triglyceride , surgery , cholesterol , endocrinology , disease , immunology , platelet , antibody
The efficacy and safety of triglyceride (TG) apheresis in patients with type 2 diabetes mellitus (DM) is unclear. Diabetic complications may predispose patients to adverse events (AEs) associated with the apheresis procedure, and diabetic dyslipidemia may negatively affect the efficacy of therapeutic apheresis (TA). We investigated the effect of DM on the efficacy and complications of TA. Patients with severe hypertriglyceridemia who underwent apheresis for treatment or for the prevention of acute pancreatitis were included in this retrospective study. Epidemiological data, lipid parameters, and AEs were recorded before and after each therapeutic session. A total of 166 procedures were performed in 27 patients. Group 1 included 17 patients with type 2 DM, and Group 2 included 10 patients without DM. The mean percentage decrease in TG levels (TG%) was higher in Group 1 (71.9% vs 60.6%, P < .001). The TG% was negatively correlated with the duration of DM in Group 1 (r = −.49, P < .001). The total number of TA sessions was 142 in patients who underwent double filtration plasmapheresis and 24 in patients who underwent therapeutic plasma exchange. We observed 9 (5.4%) mild‐to‐moderate AEs. No intergroup difference was observed in the total number of AEs ( P = .06). TA is safe and effective in patients with type 2 DM with severe hypertriglyceridemia.