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Association of bioimpedance‐derived 50‐kHz phase angle as marker of body composition with electrical parameters regarding the Cole‐Cole model
Author(s) -
Yashiro Masatomo,
Kotera Hirohisa
Publication year - 2021
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.13554
Subject(s) - bioelectrical impedance analysis , medicine , phase angle (astronomy) , body mass index , extracellular fluid , zoology , extracellular , biochemistry , chemistry , physics , astronomy , biology
Our aim is to clarify the association of the bioelectrical impedance‐derived 50‐kHz phase angle (φ 50 ) with electrical parameters regarding the Cole‐Cole model and clinical parameters. A total of 440 sets of bioelectrical impedance data from pre‐ and post‐hemodialysis from 157 patients were used. Resistance at infinite frequency ( R inf ), resistance at 0 frequency ( R 0 ), capacitance of the cell membrane (Cm), and a parameter for the distribution of the time constant ( α ) were examined as electrical parameters. Normally hydrated lean tissue mass as a percentage of the dry weight ( P NHLT ), excess fluid mass as a percentage of the dry weight ( P ExF ), body mass index (BMI), age, and sex (N sex , 0 for male, 1 for female) were examined as clinical parameters. φ 50 increased with the decrease in R inf / R 0 and α and also with the increase in Cm (multiple regression coefficients [ β ]: pre/post, −0.886/−0.936, −0.175/−0.212, and 0.167/0.141), which determined the ratio of intra‐ to extracellular fluid volume (ICV/ECV), tissue homogeneity, and total cell mass. φ 50 increased with an increase in P NHLT and BMI and decrease in P ExF , N sex , and age (β: pre/post, 0.654/0.581, 0.466/0.412, −0.483/−0.473, −0.216/−0.154, and −0.145/−0.127). The concordance correlation coefficient between φ 50 for pre‐ and post‐hemodialysis ( ρ = 0.772) may be improved ( ρ = 0.950) by adding a multiplication of 0.2 and P ExF to φ 50 for correction. φ 50 may be used to estimate body composition through the association with ICV/ECV, tissue homogeneity, and total cell mass. The correction for excess fluid is essential in order to use φ 50 as a marker of body composition related to nutrition.