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Nafamostat mesilate inhibits linezolid metabolism via its antioxidant effects
Author(s) -
Kuriyama Naohide,
Matsumoto Kana,
Morita Kunihiko,
Shimomura Yasuyo,
Hara Yoshitaka,
Hasegawa Daisuke,
Nakamura Tomoyuki,
Yamashita Chizuru,
Kato Yu,
Komura Hidefumi,
Nishida Osamu
Publication year - 2020
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.13545
Subject(s) - linezolid , medicine , adverse effect , pharmacology , saline , pharmacokinetics , anesthesia , staphylococcus aureus , vancomycin , biology , bacteria , genetics
Patients who undergo renal replacement therapy often exhibit a high plasma linezolid concentration. Linezolid is metabolized via oxidation. Nafamostat mesilate has antioxidant effects and is frequently used as an anticoagulant during renal replacement therapy. We aimed to investigate the effect of nafamostat mesilate on plasma linezolid concentration. We examined whether the co‐administration of linezolid and nafamostat had any effect on plasma linezolid concentration. Mice were randomly allocated to two groups (n = 18/group): linezolid (100 mg kg −1 , subcutaneous injection) + nafamostat (30 mg kg −1 , intraperitoneal injection) and linezolid + saline. At 5 hours, the linezolid concentration was significantly higher in the linezolid + nafamostat co‐administration group than that in the linezolid + saline group (20.6 ± 9.8 vs 3.6 ± 1.2 μg/mL, respectively P < .001). The antioxidant effects of nafamostat may inhibit linezolid metabolism, resulting in the adverse event of high linezolid concentration if both are administered concurrently during renal replacement therapy.