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Can Helicobacter pylori Colonization Affect the Phosphate Binder Pill Burden in Dialysis Patients?
Author(s) -
Korucu Berfu,
Helvaci Ozant,
Sadioglu Rezzan,
Ozbas Burak,
Yeter Hasan,
Derici Ulver
Publication year - 2020
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.13443
Subject(s) - medicine , helicobacter pylori , gastroenterology , peritoneal dialysis , proton pump inhibitor , pill , dialysis , gastrectomy , phosphate binder , hyperphosphatemia , pharmacology , kidney disease , cancer
Phosphate binder pill (PBP) burden is a significant problem in dialysis patients. Phosphate absorption through the paracellular pathway increases in relatively acidic pH. In this study, we evaluated the effect of factors contributing to duodenal pH— Helicobacter pylori (HP), proton pump inhibitors (PPIs), and NaHCO 3 capsules—on PBP burden. We evaluated 255 dialysis patients with gastric biopsies and excluded patients with low Kt/V, gastrectomy, and parathyroidectomy. Patients were divided into groups and subgroups regarding HP existence, use of PPI, or NaHCO 3 capsules. HP+ group had significantly higher PBP burden and PBP equivalent doses ( P < 0.001; both). HP+ subgroup not using daily PPIs or NaHCO 3 capsules had the highest PBP burden and PBP equivalent doses ( P < 0.001; both). HP− subgroups had similar PBP and PBP equivalent doses ( P = 0.446 and P = 0.382; respectively). HP colonization might affect the PBP burden in dialysis patients due to a decrease of duodenal pH.