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Efficacy of Plasma Exchange in Anti‐Neutrophil Cytoplasmic Antibody‐Associated Vasculitis
Author(s) -
Nishimura Keisuke,
Waki Daisuke,
Kadoba Keiichiro,
Mukoyama Hiroki,
Yokota Toshihiko,
Murabe Hiroyuki
Publication year - 2019
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12828
Subject(s) - medicine , vasculitis , creatinine , rapidly progressive glomerulonephritis , gastroenterology , survival rate , diffuse alveolar hemorrhage , anti neutrophil cytoplasmic antibody , antibody , immunology , disease
We aimed to investigate the efficacy of plasma exchange on severe anti‐neutrophil cytoplasmic antibody‐associated vasculitis (AAV). Of 182 patients with AAV in our hospital, 12 patients with life‐threatening organ damage (rapidly progressive glomerulonephritis and/or diffuse alveolar hemorrhage) underwent centrifuge‐based therapeutic plasma exchange and immunosuppressive therapy. Twenty‐four patients matched for age, serum creatinine, and severity of vasculitis, who received high‐dose glucocorticoids with or without immunosuppressants, were included in the nonplasma exchange group. Renal survival rate at 2 years from induction treatment was not significantly different between the plasma and nonplasma exchange groups ( P = 0.524). Mortality rate at 5 years from induction treatment was not significantly different between the plasma and nonplasma exchange groups ( P = 0.631). In this retrospective study, we could not show the significant differences in the renal survival rate and survival rate between the two groups.