Premium
Plasma Exchange Downregulates Activated Monocytes and Restores Regulatory T Cells in Kawasaki Disease
Author(s) -
Koizumi Keiichi,
Hoshiai Minako,
Moriguchi Takeshi,
Katsumata Nobuyuki,
Toda Takako,
Kise Hiroaki,
Hasebe Yohei,
Kono Yosuke,
Sunaga Yuto,
Yoshizawa Masashi,
Watanabe Atsushi,
Harii Norikazu,
Goto Junko,
Kagami Keiko,
Abe Masako,
Matsuda Kenichi,
Sugita Kanji
Publication year - 2019
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12754
Subject(s) - cd14 , cd16 , medicine , cd19 , cd8 , kawasaki disease , monocyte , immunology , inflammation , immune system , microbiology and biotechnology , endocrinology , cd3 , biology , artery
In Kawasaki disease (KD), the effect of plasma exchange (PE) on immune cells has not been fully elucidated. Therefore, we examined the changes in the number of CD14 + CD16 + activated monocytes, regulatory T (T reg ), and T‐helper type 17 (Th17) cells in KD patients treated with PE. The percentage of total monocytes and subclasses of lymphocytes, including CD4 + and CD8 + T cells, and CD19 + B cells, showed no significant difference before and after PE. However, the percentage of CD14 + CD16 + monocytes in total leukocytes decreased significantly after PE (1.1% ± 1.5% vs. 2.1% ± 2.3%, P < 0.05). Furthermore, while the percentage of Th17 cells in CD4 + T cells did not change, the percentage of T reg cells in CD4 + T cells increased significantly after PE (11.1% ± 5.1% vs. 8.0% ± 4.4%, P < 0.05). Therefore, PE downregulates activated monocytes and upregulates T reg cells toward normal levels and thus attenuates inflammation in KD.