Premium
Simple Formula for Predicting Drug Removal Rates During Hemodialysis
Author(s) -
Urata Motoki,
Narita Yuki,
Fukunaga Masaki,
Kadowaki Daisuke,
Hirata Sumio
Publication year - 2018
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12675
Subject(s) - hemodialysis , medicine , volume of distribution , drug , pharmacokinetics , distribution (mathematics) , distribution volume , urology , pharmacology , chromatography , mathematics , chemistry , mathematical analysis
The present study sought to derive a simple formula for predicting the drug removal rates during hemodialysis. We examined the relationship between drug removal rates during hemodialysis and the molecular weights or pharmacokinetic parameters of injectable drugs ( N = 90) obtained from pharmaceutical interview forms in Japan. Stepwise multiple regression analysis with the removal rate by hemodialysis as the objective variable adjusted for molecular weight or pharmacokinetic parameters as explanatory variables, showed that the logarithm of molecular weight (B = −18.87), the protein binding rate (B = −0.40), and the fraction of the unchanged drug excreted into the urine/volume of distribution (B = 0.05) were significantly and independently associated with drug removal rate by hemodialysis (α = 90.78, adjusted R 2 = 0.64, P = 2.2e −16 ). Our data demonstrated that molecular weight, protein binding rate, and volume of distribution were important factors affecting drug removal during hemodialysis, and that our simple regression equation could be used to predict the drug removal rate during hemodialysis.