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Compositional Analysis of Coronary Artery Calcification in Dialysis Patients in vivo by Dual‐Energy Computed Tomography Angiography
Author(s) -
Nishizawa Yoko,
Higuchi Chieko,
Nakaoka Takashi,
Omori Hisako,
Ogawa Tetsuya,
Sakura Hiroshi,
Nitta Kosaku
Publication year - 2018
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12662
Subject(s) - medicine , calcification , hemodialysis , peritoneal dialysis , dialysis , radiology , artery , cardiology , computed tomography
Abstract While vascular calcification is an important factor regulating prognosis in dialysis patients, its components have not been adequately studied. We analyzed in vivo components of calcification in the coronary arteries of dialysis patients using the effective atomic number from dual‐energy computed tomography. In dialysis patients (hemodialysis, N = 10; peritoneal dialysis, N = 12), average of median effective atomic number was 13.8 in the hemodialysis group, and 13.7 in the peritoneal dialysis group. No significant differences were seen between groups, with calcium oxalate monohydrate identified as the most common component in each. To confirm the accuracy of this method, we investigated the composition of surgically removed calcified tissues using already established methods. Comparison with the effective atomic number from dual‐energy computed tomography showed that the results of calcification analysis were the same. We concluded that calcium oxalate monohydrate might be one of the major components of coronary artery calcification in dialysis patients.