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Body Composition and Inflammation in Hemodialysis Patients
Author(s) -
Mandic Ante,
Cavar Ivan,
Skoro Ivana,
Tomic Ivan,
Ljubic Kristina,
Coric Slavica,
Mikulic Ivanka,
Azinovic Igor,
Pravdic Danijel
Publication year - 2017
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12575
Subject(s) - medicine , albumin , hemodialysis , volume overload , dialysis , c reactive protein , natriuretic peptide , serum albumin , body mass index , endocrinology , inflammation , gastroenterology , heart failure
The volume state of dialysis patients is important in guiding the dialysis process. Volume overload in these patients is associated with inflammation. The objectives of the present study were to assess the body composition of patients on hemodialysis; to determine the concentrations of B‐type natriuretic peptide (BNP) in plasma and evaluate the association of BNP concentrations with volume overload; to determine the concentrations of C‐reactive protein (CRP), albumin and superoxide dismutase (SOD) activities as indicators of inflammatory or antioxidant processes. The study included 79 maintenance hemodialysis patients. Assessment of body compartments was carried out using a body composition monitor (BCM). After BCM measurements, blood samples were taken from the patients for laboratory tests. There were 40 (50.6%) volume‐overloaded patients (relative overhydration >15%). These patients had a higher prevalence of arterial hypertension ( P < 0.05), significantly higher concentrations of BNP ( P = 0.01), lower body mass index ( P < 0.05) and lower fat tissue index ( P < 0.05). There was a positive correlation between plasma BNP and CRP concentrations (ρ = 0.231; P < 0.05), and a negative correlation between (log) BNP and albumin ( r = −0.021; P < 0.05), as well as (log) CRP and albumin concentrations ( r = −3; P < 0.01). SOD activity was positively correlated with albumin concentrations ( r = 0.254; P < 0.05). The concentrations of BNP in this study were associated with volume overload and inflammatory markers. Patients with a higher albumin concentration had higher SOD activity.