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Efficacy and Usefulness of New Single‐Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis in Active Ulcerative Colitis Patients Without Corticosteroids and Biologics
Author(s) -
Shimazu Keiji,
Fukuchi Takumi,
Kim Insung,
Noguchi Yuki,
Iwata Megumi,
Koyama Shintaro,
Ubukata Satoshi,
Tanaka Atsuo
Publication year - 2016
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12470
Subject(s) - medicine , apheresis , ulcerative colitis , adverse effect , gastroenterology , corticosteroid , granulocyte , intensive care , surgery , platelet , intensive care medicine , disease
Intensive granulocyte and monocyte adsorptive apheresis (GMA) twice weekly is effective and safe for patients with active ulcerative colitis (UC), but the requirement for maintaining two blood access routes is problematic. Here we compared the efficacy and safety of one‐route blood access intensive GMA using a single‐needle (SN) and conventional two‐route blood access intensive GMA using a double‐needle (DN) in patients with active UC not undergoing corticosteroid therapy. Among 80 active UC patients, 38 patients received SN intensive GMA and 42 patients received DN intensive GMA. The clinical remission ratio and mucosal healing ratio at 6 weeks, and the cumulative non‐relapse ratio at 52 weeks did not differ significantly between groups. In addition, no serious or mild adverse effects were observed in SN intensive GMA. SN intensive GMA may be an adequate and novel therapeutic option for active UC as an alternative therapy before using corticosteroids.