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Diagnostic Accuracy of Serum Cystatin C for the Evaluation of Renal Dysfunction in Diabetic Patients: A Meta‐Analysis
Author(s) -
Yang Shikun,
Liu Jun,
Zhang Xianming,
Hu Chun,
Zhang Wei,
Sun Lin,
Zhang Hao
Publication year - 2016
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12462
Subject(s) - medicine , cystatin c , creatinine , diagnostic odds ratio , renal function , likelihood ratios in diagnostic testing , odds ratio , gastroenterology , receiver operating characteristic , meta analysis , urology
This study aimed to evaluate the diagnostic value of serum cystatin C for renal dysfunction in diabetic patients. Eligible trials were searched from multiple databases, the data were extracted into a 2 × 2 table after the quality assessment of included articles. The pooled sensitivity, specificity and other parameters of accuracy of cystatin C were analyzed using Stata version 12.0. Seventeen studies involving 2173 patients were included. The pooled sensitivity and specificity of serum cystatin C for the diagnosis of renal dysfunction were 0.88 (95% CI: 0.83–0.91) and 0.87 (95% CI: 0.82–0.91), respectively. The positive likelihood ratio was 6.69 (95% CI: 4.83–9.26), negative likelihood ratio was 0.14 (95% CI: 0.10–0.20) and diagnostic odds ratio (DOR) was 46.57 (95% CI: 27.76–78.13). The area under the receiver operating characteristic curve was 0.94. Analysis of the 12 studies that investigated serum creatinine indicated that serum cystatin C was more accurate than serum creatinine for the diagnosis of renal dysfunction. Our results indicate that serum cystatin C is an effective index in diagnosing renal dysfunction comparing serum creatinine, serum cystatin C is more sensitivity for evaluation of renal function in diabetic patients.