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Post‐Transplant Lymphoproliferative Disorder in Kidney Transplant Recipients: A Single‐Center Experience in Japan
Author(s) -
Ishihara Hiroki,
Shimizu Tomokazu,
Unagami Kohei,
Hirai Toshihito,
Toki Daisuke,
Omoto Kazuya,
Okumi Masayoshi,
Imai Yoichi,
Ishida Hideki,
Tanabe Kazunari
Publication year - 2016
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12392
Subject(s) - medicine , post transplant lymphoproliferative disorder , lymphoproliferative disorders , single center , incidence (geometry) , transplantation , complication , pediatrics , retrospective cohort study , lymphoma , rituximab , physics , optics
Abstract Post‐transplant lymphoproliferative disorder is a serious complication of solid organ transplantation; however, few large studies have been performed in Asian institutions. We review our single‐center experience with post‐transplant lymphoproliferative disorder patients in Japan. We retrospectively evaluated patients with post‐transplant lymphoproliferative disorder following kidney transplantation between January 1985 and December 2013. The patients were divided into early‐onset post‐transplant lymphoproliferative disorder (<1 year) and late‐onset post‐transplant lymphoproliferative disorder (≥1 year) groups. Thirteen patients had the disorder, an incidence rate of 0.75% (13/1730). Early‐onset post‐transplant lymphoproliferative disorder ( N = 3) had not occurred for the last two decades. In the late‐onset group ( N = 10), the median time of onset was 108.7 months. The Kaplan–Meier 10‐year overall survival rates were 76.9% and 95.4% in patients with and without the disorder, respectively ( P = 0.0001). Post‐transplant lymphoproliferative disorder significantly affected transplant recipients' mortality. Late‐onset occurred even > 10 years after transplantation; therefore, long‐term monitoring of patients is needed.