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Removal Characteristics of Immunoglobulin G Subclasses by Conventional Plasma Exchange and Selective Plasma Exchange
Author(s) -
Ohkubo Atsushi,
Okado Tomokazu,
Kurashima Naoki,
Maeda Takuma,
Arai Shingo,
Miyamoto Satoko,
Itagaki Ayako,
Seshima Hiroshi,
Iimori Soichiro,
Naito Shotaro,
Sohara Eisei,
Uchida Shinichi,
Rai Tatemitsu
Publication year - 2015
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12346
Subject(s) - medicine , subclass , antibody , immunoglobulin g , albumin , plasma volume , chromatography , immunology , microbiology and biotechnology , chemistry , biology
Selective plasma exchange ( SePE ) using a selective membrane separator is a modified method of simple plasma exchange ( PE ). Immunoglobulin G ( IgG ) subclass distribution is one of the important immunological characteristics of IgG . However, there is little information regarding the removal characteristics of IgG subclasses by SePE and conventional PE . Here, we investigated the removal ratio of IgG subclasses by PE and SePE in seven patients with immunological disorders. When the mean processed volume was 0.88 plasma volume ( PV ) (corresponding to 2.12 L ), the mean percent reductions by PE were as follows: IgG , 63.2%; IgG1 , 64.5%; IgG2 , 64.0%; IgG3 , 61.4%; and IgG4 , 69.5%. When the mean processed volume was 1.18 PV (corresponding to 2.98 L ), the mean percent reductions by SePE were as follows: IgG , 51.6%; IgG1 , 55.3%; IgG2 , 52.0%; IgG3 , 53.7%; and IgG4 , 64.6%. In both PE and SePE , using albumin solution as the supplementary fluid, IgG was effectively eliminated regardless of IgG subclasses.