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Plasma Adiponectin Levels in Acute Liver Failure Patients Treated with Plasma Filtration with Dialysis and Plasma Exchange
Author(s) -
Yamamoto Hiroshi,
Nakae Hajime,
Uji Yoshitaka,
Maeda Kazuhisa,
Tani Tohru,
Eguchi Yutaka
Publication year - 2015
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12344
Subject(s) - medicine , adiponectin , liver failure , dialysis , plasma concentration , plasma levels , blood plasma , gastroenterology , urology , insulin resistance , insulin
Plasma filtration with dialysis ( PDF ) is a blood purification therapy in which simple plasma exchange ( PE ) is performed using a selective membrane plasma separator while the dialysate flows outside of the hollow fibers. Improvement of hypoadiponectinemia is considered to be a useful therapeutic approach for ameliorating fatal conditions including cardio‐metabolic and infectious disease. We investigated the effects of PDF in comparison to PE in terms of plasma adiponectin ( APN ) changes in patients with acute liver failure. Seventeen patients with liver failure were studied; PDF was performed 55 times and PE 14 times. Plasma APN levels increased significantly after PDF, while decreasing significantly after PE . PDF appears to be among the most useful blood purification therapies in acute liver failure cases in terms of increasing APN levels.