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Effect of Cellulose Acetate Beads on the Release of Transforming Growth Factor‐β
Author(s) -
Nishise Shoichi,
Abe Yasuhiko,
Nomura Eiki,
Sato Takeshi,
Sasaki Yu,
Iwano Daisuke,
Yagi Makoto,
Sakuta Kazuhiro,
Shibuya Rika,
Mizumoto Naoko,
Kanno Nana,
Ueno Yoshiyuki
Publication year - 2015
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12341
Subject(s) - medicine , cellulose , cellulose acetate , transforming growth factor , chemical engineering , engineering
Transforming growth factor‐β ( TGF ‐β) is released by activated platelets and induces the differentiation of T ‐helper 17 from naïve T cells. Contact between blood and cellulose acetate ( CA ) beads induces cytokine release, although their inflammatory effects on TGF ‐β release are unclear. We aimed to clarify the effect of CA beads on the release of TGF ‐β in vitro. We incubated peripheral blood with and without CA beads and measured platelets and TGF ‐β. Compared with blood samples incubated without beads, the platelet count and amount of TGF ‐β significantly decreased in blood samples incubated with CA beads. In conclusion, CA beads inhibited the release of TGF ‐β from adsorbed platelets. The biological effects of this reduction of TGF ‐β release during platelet adsorption to CA beads need further clarification.