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Optimum Conditions for the Efficacy and Safety of Cryofiltration Apheresis: An Analysis of Circuit Temperatures Depending on Plasma Flow Rate and Cooling Coil Lengths/Turns
Author(s) -
Nakajima Hirofumi,
Kaneko Shuzo,
Sato Yukihiro,
Takano Tomoo,
Hosino Toshihisa
Publication year - 2015
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12340
Subject(s) - medicine , volumetric flow rate , plasmapheresis , electromagnetic coil , extracorporeal , volume (thermodynamics) , plasma , analytical chemistry (journal) , mechanics , surgery , chromatography , thermodynamics , electrical engineering , physics , nuclear physics , chemistry , antibody , immunology , engineering
A system providing both appropriate cooling and warming are needed for the efficacy and safety of cryofiltration ( CF ) plasmapheresis. We measured some points of CF circuit temperatures with varying plasma flow rates ( Q P = 10–40 mL/min) and the numbers of connecting cooling coils (one or two) under the conditions of blood flow rate ( Q B ) 100 mL/min with 7700‐mm coil length, 19 turns, and 50‐mL priming volume. We measured the respective temperatures of each point of starting/returning for an extracorporeal circuit ( T A / T V ), intracooling coil ( T C ), and post‐plasma fractionator ( PF ) ( T PF ). The subtraction of T V from T A ( ΔT ) was used as an indicator of safe return. There were no significant differences in T C , T PF , or ΔT in accordance with each Q P between that of one and two coils. All of the T c values under the condition Q P ≤ 20 mL/min achieved <4°C. The T PF under the condition Q P ≥ 20 mL/min was not significantly different compared to that of Q P 30 mL/min (the lowest condition). Although the ΔT increased depending on the Q P increase, the ΔT under the condition Q P ≤ 15 mL/min was not significantly different from that of the control (one‐way double‐filtration plasmapheresis [ DFPP] ) group. We conclude that (i) one coil is enough for effective cooling in CF , and (ii) an ideal Q P that fulfills the required conditions for both effective cooling and sufficient warming of returning fluid does not exist, but Q P from 15 to 20 mL/min may be a relevant range.