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Association Between Angiotensin‐Converting Enzyme 2 and Coronary Artery Calcification in Patients on Maintenance Hemodialysis Therapy
Author(s) -
Zhang Qiankun,
Sun Lina,
Jin Lie
Publication year - 2015
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12298
Subject(s) - medicine , diabetes mellitus , cardiology , univariate analysis , hemodialysis , logistic regression , body mass index , pathogenesis , calcification , endocrinology , multivariate analysis
While all mechanisms that contribute to the pathogenesis of coronary artery calcification ( CAC ) are unknown, angiotensin‐converting enzyme 2 ( ACE 2) may be involved in this process in maintenance hemodialysis ( MHD ) patients. The aim of this study was to investigate the association between ACE 2 and CAC in patients on MHD therapy. Ninety patients on MHD therapy were involved in this prospective study. CAC was quantified by CAC score ( CACs ) using the A gatston method and a multi‐slice CT scanner. Univariate and multivariate logistic regression were used to analyze the association between ACE 2 and CACs . In the univariate analysis, CACs positively correlated with ACE 2 (r = 0.666, P < 0.001). After adjusting for age, sex, smoking, hypertension, body mass index, diabetes mellitus, and hyperlipidemia, ACE 2 levels continued to significantly and independently predict the presence of CAC . ROC curve analysis showed that the serum ACE 2 level can predict the extent of CAC . These findings indicate that elevated serum ACE 2 may be involved in vascular calcification in patients receiving MHD therapy.