Premium
Extracorporeal Treatment in Severe Hypertriglyceridemia‐Induced Pancreatitis
Author(s) -
Zeitler Heike,
Balta Zeynep,
Klein Burkhard,
Strassburg Christian P.
Publication year - 2015
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12286
Subject(s) - medicine , plasmapheresis , hypertriglyceridemia , pancreatitis , apheresis , complication , surgery , extracorporeal , acute pancreatitis , hyperviscosity , gastroenterology , immunology , triglyceride , platelet , cholesterol , blood viscosity , antibody
Plasmapheresis is a well‐accepted treatment option in severe hypertriglyceridemia‐induced pancreatitis ( HTGP ). The rationale behind this approach is the depletion of triglycerides and the reduction of inflammatory cytokines. The time span between onset of clinical symptoms and start of plasmapheresis might have an important impact on mortality. Hyperviscosity of patients' plasma represents another special challenge for the applied separation technology. The procedures can be performed either by centrifugal device ( CFD ) or membrane based ( MBS ) units. The present study reports the outcome of 10 patients suffering from HTG . The expected mortality of the collective was 25%. Plasmapheresis was started after an average 16.3 h (SD ± 6.7 h) after onset of symptoms. No mortality occurred. Apheresis was statistically equally effective with both devices. A median of 3 sessions reduced the TG level to normal and correlated with patients' improvement. During follow up, three patients developed a pancreatic pseudocyst requiring surgical intervention without further complication.