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Is Granular Formulation of Lanthanum Carbonate More Effective than Chewable Tablets?
Author(s) -
Okamoto Hidekazu,
Haruhara Koutarou,
Kamejima Sahoko,
Mafune Hana,
Manabe Mayumi,
Kanzaki Goh,
Mashiko Hiroshi,
Yokoo Takashi
Publication year - 2014
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12207
Subject(s) - lanthanum carbonate , medicine , lanthanum , gastroenterology , calcium , hyperphosphatemia , inorganic chemistry , chemistry
Maintenance dialysis patients at our hospital who had been receiving lanthanum carbonate ( LC ) chewable tablets were switched to the same dosage of the granules, and the differences in serum phosphorus ( P ) levels were compared, together with stratifying patients at the baseline characteristics. Compared to average serum P level of 5.48 mg/ dL for 2 months prior to switching, the average level for 2 months after switching was 4.99 mg/ dL ( P = 0.049). For patients who were under 60, serum P levels were significantly improved after switching ( P = 0.016), and for patients who were concomitantly taking many kinds of medications, a correlation to high reductions of serum P level after switching was shown ( R = −0.635, P = 0.015). In order to maximize pharmaceutical potential of LC , we think that it is not only necessary to provide patients with how to take the medication, but it is also important to take into consideration the patients' baseline characteristics.