Multicenter Study on the Long‐Term (3‐Year) Efficacy of Lanthanum Carbonate in Dialysis Patients | Zendy

Ando Ryoichi | Zendy; Yama Satomi | Zendy; Ohnishi Tsuyoshi | Zendy; Iwamoto Shunsuke | Zendy; Kimura Hitoshi | Zendy; Chida Yoshiko | Zendy; Ishida Yuji | Zendy; Yamada Kouei | Zendy; Inagaki Yuichiro | Zendy; Takayama Masanobu | Zendy; Tachibana Ken | Zendy; Kikuchi Kan | Zendy; Inoue Atsushi | Zendy; Ohtsuka Masakazu | Zendy

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Multicenter Study on the Long‐Term (3‐Year) Efficacy of Lanthanum Carbonate in Dialysis Patients

Author(s) -

Ando Ryoichi,

Yama Satomi,

Ohnishi Tsuyoshi,

Iwamoto Shunsuke,

Kimura Hitoshi,

Chida Yoshiko,

Ishida Yuji,

Yamada Kouei,

Inagaki Yuichiro,

Takayama Masanobu,

Tachibana Ken,

Kikuchi Kan,

Inoue Atsushi,

Ohtsuka Masakazu

Publication year - 2014

Publication title -

therapeutic apheresis and dialysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.415

H-Index - 53

eISSN - 1744-9987

pISSN - 1744-9979

DOI - 10.1111/1744-9987.12206

Subject(s) - lanthanum carbonate , hyperphosphatemia , medicine , parathyroid hormone , dialysis , phosphate binder , guideline , multicenter study , gastroenterology , endocrinology , calcium , randomized controlled trial , pathology

We previously conducted a multicenter study enrolling 101 dialysis patients with hyperphosphatemia in which lanthanum carbonate ( LC ) was administered for 2 years. In this study, the administration has been continued for an additional year, and we have evaluated the long‐term (a total of 3 years) effects of LC . The average serum phosphorus ( P ) level was 6.05 mg/ dL at the start and decreased to 5.84 mg/ dL after 3 years, but no significant differences were observed at both points. The average serum corrected calcium ( C a) level significantly reduced after 3 years ( P < 0.001). As results of evaluating the achievement rates with the management target values of serum P , C a and intact parathyroid hormone ( PTH ) stated in the Japanese guideline, the achievement rates increased after 3 years. From these results, LC is considered to be a useful P binder that can be used for long‐term treatment of hyperphosphatemia, without causing a C a load.

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