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Investigation of Factors Affecting the Six‐Minute Walk Test Results in Hemodialysis Patients
Author(s) -
Kono Kenichi,
Nishida Yusuke,
Moriyama Yoshihumi,
Yabe Hiroki,
Taoka Masahiro,
Sato Takashi
Publication year - 2014
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12177
Subject(s) - medicine , hemodialysis , anemia , coronary artery disease , cardiology , kidney disease , creatinine , copd , total iron binding capacity , gastroenterology , iron deficiency
Renal anemia, uremic myopathy, and malnutrition are some of the factors that affect the results of the 6‐minute walk test (6 MWT ) in hemodialysis patients. We hypothesized that skeletal muscle dysfunction caused by skeletal myolysis, protein hypercatabolism, and mitochondrial deficiency are strongly related factors. The purpose of this study was to clarify the factors that affect the 6 MWT results in hemodialysis patients to assess their exercise tolerance. The study included 43 outpatients from the hemodialysis unit. The 6 MWT was performed, and knee extension strength, 1‐leg standing time, and grip were measured. In addition, the subjects' characteristics such as age, preexisting coronary artery disease, hemoglobin level, total iron binding capacity, serum albumin level, creatinine generation rate, and normalized protein catabolic rate were investigated. A stepwise multiple regression model was used to examine the factors affecting the 6 MWT results. Multiple regression analysis revealed that knee extension strength (β = 0.446, P = 0.001), total iron binding capacity (β = −0.299, P = 0.021), and preexisting coronary artery disease (β = −0.272, P = 0.035) significantly affected the 6 MWT results (R = 0.66, R 2 = 0.44). The 6 MWT in hemodialysis patients was strongly affected by muscle strength, iron deficiency anemia, and preexisting coronary artery disease, suggesting that resistance training is important for improving 6 MWT results. Our findings indicate that iron deficiency and cardiac function should be assessed before exercising or undergoing an exercise tolerance test.