Solute Removal Capacity of High Cut‐Off Membrane Plasma Separators

In vitro blood filtration was performed by a closed circuit using high cut‐off membrane plasma separators, EVACURE EC ‐ 2A10 ( EC ‐ 2A ) and EVACURE EC ‐ 4A10 ( EC ‐ 4A ). Samples were obtained from sampling sites before the plasma separator, after each plasma separator, and from the ultrafiltrate of each separator. The sieving coefficient ( S . C .) of total protein ( TP ), albumin ( Alb ), IgG , interleukin‐6 ( IL ‐6), interleukin‐8 ( IL ‐8), tumor necrosis factor‐α ( TNF ‐α), fibrinogen ( Fib ), antithrombin III ( AT‐III ), and coagulation factor XIII ( FXIII ) were calculated. The S . C . of each solute using EC ‐ 2A and EC ‐ A4 were as follows; TP : 0.25 and 0.56, Alb : 0.32 and 0.73, IgG : 0.16 and 0.50, IL ‐6:0.73 and 0.95, IL ‐8:0.85 and 0.82, TNF ‐α: 1.07 and 0.99, Fib : 0 and 0, FXIII : 0.07 and 0.17, respectively. When compared with the conventional type of membrane plasma separators, EVACURE could efficiently remove cytokines while retaining coagulation factors such as fibrinogen. Moreover, EC ‐ 2A prevented protein loss, whereas EC ‐ 4A could remove approximately 50% of IgG .