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Fibroblast Growth Factor 23 and Left Ventricular Mass Index in Maintenance Hemodialysis Patients: Standard Versus Long Nocturnal Hemodialysis
Author(s) -
Knap Bojan,
VečerićHaler Željka,
Benedik Miha,
ButurovićPonikvar Jadranka,
Ponikvar Rafael,
Bren Andrej F
Publication year - 2013
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12087
Subject(s) - medicine , fibroblast growth factor 23 , left ventricular hypertrophy , hemodialysis , dialysis , population , cardiology , renal function , end stage renal disease , endocrinology , nocturnal , kidney disease , urology , gastroenterology , parathyroid hormone , blood pressure , environmental health , calcium
Elevated levels of fibroblast growth factor 23 ( FGF23) and phosphorus ( P ) have been linked to greater risks of left ventricular hypertrophy ( LVH ) in patients with end stage renal disease ( ESRD ). The aim of this study was to test if differences exist in a long nocturnal HD group in comparison with a group treated with standard daily thrice weekly dialysis. The attempt was to evaluate if elevated FGF ‐23 levels, intact parathyroid hormone and P might be associated with left ventricular mass index ( LVMI ). Quantitative echocardiographic analyses were performed at baseline in 50 maintenance HD patients (17 women and 33 men, mean age: 56.4 ± 15.35 years, mean HD vintage: 9.06 ± 8.86 years, all patients are on HD thrice a week‐median duration 15 h/week, 10 of them on long nocturnal HD , median duration 24 h/week). LVMIs were calculated. FGF23 was measured in duplicate using a second generation C ‐terminal enzyme‐linked immunosorbent assay and log of FGF ‐23 values were computed. Mean LVMI was 136.44 ± 44.44 g/m 2 . Serum FGF ‐23 levels were elevated when compared to population data with preserved kidney function (median 1388.5 RU/mL, range 252 to 24 336 RU/mL). There were no correlations recorded between log FGF ‐23 levels and LVMI (r = 0.2, P = 0.66). LVMI was significantly lower in HD patients on long nocturnal dialysis procedure (r = −0.31, P = 0.05). Patients treated with long nocturnal HD showed lower LV mass, lower P ‐values and higher 25‐ OH ‐ D 3 supply. Plasma FGF ‐23 concentration was comparable between the groups and was not associated with LVMI in our maintenance HD patients.