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Association of Increased Indoleamine 2, 3‐Dioxygenase With Impaired Natural Killer Cell Activity in Hemodialysis Patients
Author(s) -
Tanaka Asuka,
Kato Akihiko,
Suzuki Yuzo,
Suzuki Masako,
Ohmori Hiromitsu,
Sumimoto Ryo,
Ohdan Hideki
Publication year - 2014
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12071
Subject(s) - medicine , kynurenine , indoleamine 2,3 dioxygenase , hemodialysis , immune system , natural killer cell , cellular immunity , immunology , endocrinology , dialysis , tryptophan , biochemistry , biology , cytotoxic t cell , amino acid , in vitro
Indoleamine 2, 3‐dioxygenase ( IDO ) suppresses adaptive immune response. However, there was no study to examine whether IDO activity is associated with immune parameters in dialysis patients. In this study, we estimated serum IDO activity by the kynurenine/tryptophan ratio ( KTR ), and compared KTR with natural killer ( NK ) cell activity, soluble interleukin‐2 receptor ( sIL‐2R ) and serum levels of trace elements such as selenium ( S e) and zinc ( Z n) that affect T ‐cell function in 28 hemodialysis ( HD ) patients (age: 72 ± 13 years old, time on HD : 79 ± 89 months). NK cell activity was decreased in 35.7% of the patients. KTR values were almost 10‐times higher in HD patients (380.81 ± 385.46 mM/M ) than those in the referred controls (32.9 ± 9.10 mM/M ). KTR was lower in patients with impaired NK cell activity than those without (279 ± 111 vs. 565 ± 603 mM/M , P = 0.07). There was no relationship between KTR and sIL‐2R and Z n, while KTR was significantly and negatively correlated with serum S e levels that can impair cellular immunity (r = −0.41, P < 0.05). Our findings suggest that increased IDO activity with S e deficiency may be associated with impaired NK cell function in HD patients.