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Efficacy of Continuous Oral Administration of Lanthanum Carbonate over 24 months
Author(s) -
Ishizu Takashi,
Hong Zhang,
Matsunaga Tsuneaki,
Kaneko Yoko,
Taru Yoshinori
Publication year - 2013
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12042
Subject(s) - lanthanum carbonate , medicine , cinacalcet , phosphate binder , parathyroid hormone , lanthanum , phosphate , sevelamer , oral administration , carbonate , concomitant , vitamin d and neurology , endocrinology , pharmacology , calcium , secondary hyperparathyroidism , inorganic chemistry , hyperphosphatemia , biochemistry , chemistry , organic chemistry
To examine the efficacy of long‐term administration of lanthanum carbonate, changes in serum Ca , phosphate, whole parathyroid hormone ( wPTH ), and ALP were examined in 40 patients who were able to tolerate dosage of lanthanum carbonate over a continuous period of 24 months. Concurrently, concomitant administration of other phosphate binders, cinacalcet, vitamin D , etc., was also examined. After 24 months, serum phosphorus levels ( P levels) had decreased to within management target of guidelines, from 6.16 ± 1.44 mg/dL to 5.58 ± 1.15 mg/dL, and this effect was maintained for 2 years. There were no changes in Ca level. wPTH did not change significantly but tended to increase at 12 months. The dose of concomitantly administered calcium carbonate and sevelamer hydrochloride was reduced. The P ‐lowering function of lanthanum carbonate still held steady at 24 months following the start of dosage. Because of the rising trend seen in wPTH , dose of cinacalcet and/or vitamin D need to be modulated. Reducing the number of concomitantly administered phosphate binder tablets was desirable from the standpoint of patient adherence.