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O ccult H epatitis B V irus I nfection in J apanese C hronic H emodialysis P atients
Author(s) -
Nagakawa Osamu,
Miyatomi Yoshiho,
Shigeta Yasuhiro,
Inayama Emi,
Murakami Kouichi,
Sakai Takehiko,
Kouno Takashi,
Masai Motoyuki,
Shirai Kohji,
Yoshida Toyohiko
Publication year - 2013
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/1744-9987.12006
Subject(s) - medicine , occult , hemodialysis , virology , chronic hepatitis , virus , hepatitis b virus , pathology , alternative medicine
We investigated the prevalence of occult hepatitis B virus ( HBV ) infection in J apanese chronic hemodialysis patients. Hemodialysis patients ( n = 1041) were screened for occult HBV . The presence of hepatitis B surface antigen ( HBsAg ), hepatitis B surface antibody, and hepatitis B core antibody (anti‐ HBc ) was determined by various chemiluminescent immunoassays. HBV‐DNA was quantified in patients positive for anti‐ HBc using quantitative real‐time polymerase chain reaction. Among the 1041 patients, six (0.6%) were HBsAg ‐positive and 218 (20.9%) were anti‐ HBc ‐positive. All HBsAg ‐positive patients also tested positive for the presence of HBV DNA . Of 212 HBsAg ‐negative and anti‐ HBc ‐positive patients, three were positive for HBV DNA . Our study showed that the prevalence of occult HBV infection in chronic hemodialysis patients from eastern J apan was 0.3%.