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Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway
Author(s) -
Su LiDe,
Zhang QiaoLing,
Lu Zhiqiang
Publication year - 2017
Publication title -
insect science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 45
eISSN - 1744-7917
pISSN - 1672-9609
DOI - 10.1111/1744-7917.12285
Subject(s) - biology , resistance (ecology) , microbiology and biotechnology , cancer research , ecology
Bacterial infection causes enhanced reactive oxygen species (ROS) levels in insects. Oxidation resistance 1 (OXR1) plays an antioxidant role in eukaryotic organisms, including insects. In this report, we demonstrated that Pseudomonas aeruginosa and Staphylococcus aureus infection and hydrogen peroxide (H 2 O 2 ) injection induced the expression of specific transcriptional isoforms of OXR1 in larval silkworms. We further showed that a Jun kinase (JNK) pathway inhibitor, SP600125, down‐regulated expression of OXR1 during infection, leading to elevated H 2 O 2 levels in the hemolymph, resulting in lower viability of the injected bacteria inside the silkworm larvae. Our study suggests that OXR1 participates in protecting larval silkworms from oxidative stress and bacterial infection through the JNK pathway.