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Effects of an autologous fibrin sealant on lymphatic leakage after radical cystectomy: A matched case‐control study
Author(s) -
Chan Eddie ShuYin,
Yee ChiHang,
Chiu Peter KaFung,
Chan ChiKwok,
Tam Mandy HoMan,
Ng ChiFai
Publication year - 2016
Publication title -
surgical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.109
H-Index - 10
eISSN - 1744-1633
pISSN - 1744-1625
DOI - 10.1111/1744-1633.12189
Subject(s) - medicine , cystectomy , lymphocele , fibrin , surgery , sealant , bladder cancer , urology , cancer , transplantation , chemistry , organic chemistry , immunology
Aim The aim of the present study was to investigate the effect of an autologous fibrin sealant ( V ivostat) on the prevention of lymphatic leakage after radical cystectomy. Patients and M ethods Patients who underwent laparoscopic radical cystectomy ( LRC ) or robot‐assisted radical cystectomy ( RARC ) for the treatment of bladder cancer were enrolled. Autologous fibrin sealant was applied after the completion of bilateral pelvic lymph node dissection. The data were compared with those from matched RARC patients in a historical cohort. Results Ten consecutive RARC or LRC were performed using an autologous fibrin sealant. A statistically nonsignificant reduction in drain output (1165.5 m L , range = 225–3150 m L ) was observed compared with 10 matched historical RARC patients who did not receive the autologous fibrin sealant (1927.2 m L , range = 240–4010 m L ). No difference in the number of days of in‐situ drainage or the length of hospital stay was found. Two patients in the control group developed asymptomatic lymphocele. One patient in the group treated with the autologous fibrin sealant developed deep vein thrombosis after RARC . Conclusion The use of an autologous fibrin sealant did not reduce lymphatic leakage after radical cystectomy.