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Giant condyloma acuminatum of B uschke– L owenstein tumour: Disease development between 2000 and 2010
Author(s) -
Safi Farouk,
Bekdache Omar,
AlSalam Suhail,
Alashari Mouied,
Mazen Taha
Publication year - 2014
Publication title -
surgical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.109
H-Index - 10
eISSN - 1744-1633
pISSN - 1744-1625
DOI - 10.1111/1744-1633.12047
Subject(s) - medicine , malignancy , condyloma acuminatum , malignant transformation , benignity , dermatology , lesion , disease , human papillomavirus , surgery , pathology
Aim Giant condyloma acuminatum, originally described by B uschke and L owenstein in 1925 as a lesion of the penis, is more rarely seen in the anorectum, and is characterized by clinical malignancy in the face of histological benignity; however, malignant transformation in approximately one‐third of patients to invasive squamous cell carcinoma has been described. Malignant transformation has been reported in patients with ‘ordinary’ condylomata acuminata as well. Human papillomavirus, known to cause condylomata acuminata, is also known to induce these tumours, and was found in 96 per cent of the 63 cases reviewed in the past 10 years. Radical R0 excision, independent of used surgical methods, as well as vigilant follow up, provides hope for cure. Conservative and/or multimodal therapy has been demonstrated in a few cases; however, its effect is not yet clear. Patients and Methods In the present study, we reviewed literature published between 2000 and 2010 and compared these with previous reviews. Results We found an increase in published cases per year of g iant c ondyloma acuminatum. Sex ratios (3:1, m ale : f emale), mean age (42 years) and symptoms were found to be equal in this and previous reviews. Conclusions Our research found that there were more viral studies on specimens in order to understand the disease, and a less transformation rate to malignancy was found. Surgery is still the preferred practice for treating patients.