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Correlations Among the HLA ‐ DQB 1 Alleles and Suicidal Behavior
Author(s) -
Matei Horea V.,
Vică Mihaela L.,
Ciucă Irina,
Coman Horia G.,
Nicula Gheorghe Z.,
Siserman Costel V.
Publication year - 2020
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/1556-4029.14166
Subject(s) - human leukocyte antigen , allele , genotype , immunology , histocompatibility , polymerase chain reaction , genetic predisposition , medicine , genetics , gene , antigen , biology
Suicide is a worldwide health problem with multiple causes, including genetic factors. The major histocompatibility complex ( MHC ) is represented by an assembly of gene encoding the human leukocyte antigen ( HLA ). The purpose of our study was to determine associations between the HLA profiles and predisposition for suicidal behavior. We harvested blood samples from persons with history of suicidal attempts (case group) and persons never exhibiting such behavior (control group). The DNA was extracted and amplified via polymerase chain reaction ( PCR ) to determine the HLA ‐ DQB 1 profiles. Statistical data processing was performed with the Epi Info program. We found that the presence of the HLA ‐ DQB 1*02 allele increases the risk of suicidal behavior, while HLA ‐ DQB 1*05 alleviates such risk. The genotype that presented the most increased risk for suicidal behavior was found to be HLA ‐ DQB 1*02/ HLA ‐ DQB 1*03. Our study has demonstrated the presence of several associations between HLA profiles and suicidal behavior.